(1) A SNP or Single Nucleotide Polymorphism occurs when a single nucleotide differs from the majority (wild type is considered the “normal” expected nucleotide)
(2) SNPs occur in coding regions, non-coding regions or between genes (intergenic). We look at the coding regions.
(3) SNPs vary in terms of severity and benefit due to location and redundancy. Our bodies typically have back-up pathways for redundancy. So for example, estrogen breakdown via the Phase II liver sulfation pathway is backed-up by the Phase II liver glucaronidation pathway. The sulfation (SULT SNPs can affect) pathway can accept a larger variety of intermediate metabolites, but will defer to the glucaronidation pathway when it gets overwhelmed, so both pathways need to be working optimally.
(4) Most SNPs do NOT govern genetic function and expression. Diet and lifestyle do.
(5) SNPs may cause gene instability due to decreased cofactor affinity. A cofactor can be a vitamin, mineral or other byproduct of biochemical pathway processing (e.g., NAPD)
(6) SNPs may be bypassed by increasing cofactor concentration and providing end products directly. So for example, if you have an MTHFR C677T down-regulation, you can “bypass” the down-regulation via delivery of 5 MTHF (folate) as a supplement. Having said that though, its much more complicated, as the biochemical pathways interconnect. If you simply address one SNP in isolation, you run the risk of mucking up other pathways. I’ve seen this many times where a person takes a high dose of 5-MTHF (e.g., Deplin) without considering neighboring enzymes (affected by SNPs). The improper supplementation can result in feeling great for a few days, then tired, to experiencing increased anxiety.
The Compendium 1 is currently 330 pages and includes the following SNP categories:
- Phase 1 and 2 Liver Detox SNPs
- Methylation SNPs
- Alcohol SNPs
- Histamine SNPs
- Neurotransmitter SNPs
- Mitochondrial SNPs (Electron Transport Chain)
This SNPBit Compendium 1 is a compilation of four years of research gathered by Sterling and Cynthia, and our associate Carolyn Ledowsky.
The current SNPBit Compendium 1 will be updated shortly. Its next edition will include updates to the current enzymes/SNPs, additional sections/pathways such as the Pentose Phosphate Pathway, and more.